Amgen Associate Scientist: Therapeutic Antibody Discovery - Screening (12 month contract) in Burnaby, British Columbia

Title: Associate Scientist: Therapeutic Antibody Discovery, Screening (12-month contract)

Location: Burnaby

Req#: R-42863


Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions.

Amgen British Columbia, located in Metro Vancouver, Canada, is a research center of excellence focused primarily on the use of XenoMouse® technology for the discovery of fully human therapeutic monoclonal antibodies. This team is seeking a highly motivated and experienced researcher to help us advance our therapeutic antibody discovery efforts.

The incumbent will complement an innovative group with a strong track record of success in pioneering novel antibody-based therapeutics to treat grievous illnesses. The role will be laboratory-based, supporting multiple diverse therapeutic discovery programs, in addition, to bringing forward crucial new concepts and techniques to identify therapeutic candidates with extreme functional design goals.

This is a key position in our cell-based screening group which is primarily focused on the early identification of therapeutic monoclonal antibodies. The principle responsibilities of this position will involve performing experiments, organizing large data sets, as well as recording, analyzing and interpreting results. The ideal candidate should have experience in higher throughput cell-based screening methods including flow cytometry and/or plate based readers. The position requires strong problem solving and scientific skills with the ability to work across multiple concurrent projects and knowledge of common software platforms and database management methods. Additional responsibilities include maintaining laboratory notebooks and electronic files, as well as participating and presenting scientific data in group and departmental meetings. Strong inter-personal skills and an ability to work in a highly dynamic team environment are essential. The candidate will be expected to have excellent written and oral communication skills.

This role will also be involved in assay development and design, scientific analysis, problem solving and creativity.

Basic Qualifications

Bachelors OR Master's degree

Preferred Qualifications

2+ years' experience in one or more antibody discovery technologies (e.g. hybridoma, phage display, B cell recovery (SLAM), nanoscale screening, gel microdrop, NGS, etc.)

Assay development to support large molecule screening

Knowledge of FACS based binding assays and analysis

3+ year's relevant post-doctoral research or equivalent industry experience in therapeutic antibody discovery field

Proficiency in screening characterization platforms; Biacore, ForteBio, etc

Large molecule discovery and development experience

Proficient in the use of flow cytometers as well as the ability to plan, execute and interpret a flow cytometric experiment

Experience with microscopy-based cell biology studies. Confocal imaging experience would be an asset.

Mammalian tissue culture

Experience in a working environment requiring strong inter-personal and communication skills across a broad range of audiences including senior scientists and leaders throughout an organization

Experience in a role requiring strong problem solving and scientific skills

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Reasonable accommodations are available, upon request, to facilitate the equal participation of candidates with disabilities, should you be selected for an interview.